What is Turkesterone and how may it help me gain muscle?

 What exactly is Turkesterone?

 

Turkesterone is an ecdysteroid, which is a type of chemical that acts as a growth factor in plants and insects. Consider ecdysteroids to be a type of hormone that promotes cellular development. They control molting, growth, and morphogenesis in insects. They repel predators in plants. They may also promote muscle protein synthesis in mammals. For this effect, several paths have been proposed:

 

First, turkesterone has been shown in in vitro tests to boost the efficiency of muscle protein synthesis by more than 100%. (and increasing rat grip strength in vivo).

 

Second, turkesterone may enhance the amount of leucine incorporated by a particular cell. You may recall that leucine is the most anabolic amino acid available.

 

Finally, ecdysteroids such as turkesterone may bind to the beta-type estrogen receptor, which is linked to increased bone and muscular growth rather than the more stereotypical "feminizing" effects of other estrogen receptor types.

 

Are Turkesterone Supplements Effective?

 

It's difficult to say. Although there have been few human trials on turkesterone supplementation, there have been some excellent animal studies on turkesterone and related ecdysteroids. Consider the following:

 

Despite no changes in training/swimming volume, rats given ecdysteroids were stronger and longer swimmers than rats given a placebo.

Sheep given the supplement gained weight more quickly and produced more wool. This shows that it is more than just a stimulator of raw mass gain; it also improves the organism's function (wool production). Furthermore, turkesterone had an even larger effect on sheep who were not supplied enough grain.

An earlier Russian study discovered that turkesterone boosted muscle protein synthesis in the liver about as much as anabolic steroids.

Turkesterone also appears to boost the resistance of mice subjected to "immobility stress"—the restriction of unrestricted movement in lab mice. This is the most consistent approach to elicit a stress response in mice. Immobility stress causes the adrenal glands to expand, the immune system to weaken, cholesterol and vitamin C levels to diminish, and the gut lining to degenerate in normal mice. These alterations do not occur as soon in mice given turkesterone (or at all).

 

In the absence of human studies, what can we learn from animal studies?

 

Human research begins with animal studies. We all have identical processes for muscle acquisition, growth, and loss as animals. To be sure, there are distinctions, but there are also many similarities and redundancies.

 

Anecdotal reports from turkesterone users on internet message boards and social media are also plentiful. You can't base public health policy or publish studies on anonymous Reddit reports, but you can read them for yourself and decide whether or not they're believable. Then you can decide whether or not to try the supplement.

 

And, if you look back at previous Russian studies, you'll notice some remarkable findings. Unfortunately, I am unable to verify them. They are all unavailable as whole studies or even abstracts, and even if they were, they would be in Russian. All I saw was an unverified list of the results. Nonetheless, here they are:

 

Anti-anxiety

Wound healing has been improved.

Reduce blood glucose levels

Inflammation has been reduced.

Adaptogenic properties

Anti-arrhythmia

In other words, these compounds are said to perform all of the "Good Stuff" that you look for in a supplement. That could be the case, but I can't confirm it.

 

Is Turkesterone a natural hormone?

 

Turkesterone is a naturally occurring ecdysteroid found mostly in the plant Ajuga Turkestanica. This plant is the source of all commercial turkesterone supplements. They are plant extracts that are just as "natural" as any other plant extract you would take.

 

Is There a Negative Side Effect ofTurkesterone?

 

Common (though not guaranteed) adverse effects include nausea, diarrhea, and upset stomach, frequently at higher doses than suggested.

 

Fortunately, turkesterone looks to be exceedingly safe and non-toxic even at high levels. The majority of research suggest that benefits begin around 10 mg per kilogram of bodyweight, while oral toxicity emerges above 9000 mg per kilogram of bodyweight. There is no danger in taking anything close to 9000 mg, let alone 9000 mg per kilogram of bodyweight.

 

Overall, if you can afford turkesterone, are interested in growing lean mass (or any of the other potential benefits), and are already exercising hard, eating well, sleeping enough, and doing everything else you're supposed to be doing, I'd give it a month's trial. Try to keep everything else consistent—diet, training, sleep, and stress—so you can isolate any supplement effects.

 

But if you're barely training, staying up late, and eating poorly, don't expect turkesterone to help you. Only attempt it if you're already doing everything correctly.

 

If research on anabolism in animals on reduced calorie intakes are any indication, turkesterone may also be beneficial for retaining or even building muscle when cutting weight.

 

It appears to be promising to me. The primary disadvantage is that it is not inexpensive, and it is difficult to obtain high-quality turkesterone that you can rely on. These appear to be the best products available: True Nutrition, Gorilla Mind

 

Do you have any personal experience with turkesterone? I'd love to know how it went — or didn't go — for you.

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